Home Health Omega-3 fatty acids and the guts: New proof, extra questions

Omega-3 fatty acids and the guts: New proof, extra questions

My sufferers generally ask me whether or not they need to attempt one complement or one other. Usually my reply is equivocal, as a result of for many dietary supplements we simply don’t have sufficient proof to provide a particular reply. This doesn’t imply {that a} explicit affected person couldn’t profit from a selected complement; it simply means I don’t have standardized analysis to information my suggestions. Sadly, this stays true of omega-3 fatty acid dietary supplements. The outcomes of research omega-3 dietary supplements have been inconsistent, and have left each physicians and sufferers questioning what to do.

Omega-3 fatty acids present profit in REDUCE-IT trial and win FDA approval

Two foremost omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are discovered primarily in fish and fish oil. Omega-3s from fish and fish oil have been advisable by the American Coronary heart Affiliation (AHA) for the previous 20 years to cut back cardiovascular occasions, like coronary heart assault or stroke, in individuals who have already got heart problems (CVD). I’ve written about and been a robust advocate of getting omega-3s via food plan, and typically via using dietary supplements.

Over the previous 12 months I’ve prescribed an omega-3, offered underneath the model identify Vascepa, to my sufferers who’re at excessive threat for CVD, primarily based on proof of cardiovascular advantages. Vascepa accommodates purified EPA, and its use relies on good medical information from the REDUCE-IT trial. This research enrolled over 8,000 sufferers with elevated cardiovascular threat and excessive blood triglyceride ranges. They assigned half of the research contributors to obtain 2 grams of Vascepa twice a day, and assigned the opposite contributors a placebo (a tablet crammed with mineral oil). The outcomes confirmed a major good thing about Vascepa over the placebo. Vascepa diminished blood triglyceride ranges, however extra importantly, it diminished the variety of coronary heart assaults and strokes, the necessity for a coronary heart stenting process to open clogged arteries, and demise.

A subsequent meta-analysis, which included information from over 10 research, discovered fish oil omega‐3 dietary supplements lowered threat for coronary heart assault and demise from coronary coronary heart illness.

In December 2020, the FDA authorised using Vascepa to cut back the danger of cardiovascular occasions in sure sufferers with, or at excessive threat for, CVD.

STRENGTH trial casts some doubt on omega-3 advantages

However a current research has raised some questions. The STRENGTH trial, revealed in JAMA, checked out a distinct formulation of omega-3 fish oil — a mixture of EPA and DHA — to see if it will additionally scale back cardiovascular threat. This research enrolled over 13,000 sufferers who had been randomized to obtain both the EPA/DHA mixture tablet or the placebo (a tablet crammed with corn oil). The trial was terminated early attributable to an interim evaluation revealing no distinction between the 2 therapy teams.

We don’t know for sure why the REDUCE-IT trial confirmed a profit from omega-3s whereas the STRENGTH trial didn’t. One risk is that the completely different outcomes are as a result of completely different medication studied. REDUCE-IT studied a purified formulation of high-dose EPA, which resulted in increased EPA ranges. This was just like the outcomes of another trial, which additionally discovered that pure EPA diminished the danger of cardiac occasions. The STRENGTH trial examined a mixture of EPA and DHA. No massive research has ever evaluated the results on cardiovascular outcomes of purified DHA alone, leaving us to wonder if DHA may counteract the advantages of EPA.

The place can we stand?

Again to my sufferers who need to know if they need to be taking an omega-3 complement. With the provision of at the moment’s information, I might suggest a pure EPA complement, or one which accommodates extra EPA than DHA. However don’t cease there. Eat a heart-healthy food plan, get common train, and pursue other lifestyle changes which have confirmed advantages for cardiovascular well being. Within the meantime, my colleagues and I anticipate extra definitive information on the utility of omega-3 fish oil, and who may profit essentially the most.

The submit Omega-3 fatty acids and the heart: New evidence, more questions appeared first on Harvard Health Blog.

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